Article
Reaction mechanism of Drosophila cryptochrome.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2011
Ozturk Nuri, Selby Christopher P, Annayev Yunus, Zhong Dongping, Sancar Aziz
Abstract excerpt
Cryptochrome (CRY) is a blue-light sensitive flavoprotein that functions as the primary circadian photoreceptor in Drosophila melanogaster. The mechanism by which it transmits the light signal to the core clock circuitry is not known. We conducted in vitro studies on the light-induced conformational change in CRY and its effect on protein-protein interaction and performed in vivo analysis of the lifetime of the...
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