Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allosteric modulation of ghrelin receptor signaling by lipids.

Nature communications - 24 Jun 2021

Damian Marjorie, Louet Maxime, Gomes Antoniel Augusto Severo, M'Kadmi Céline, Denoyelle Séverine, Cantel Sonia, Mary Sophie, Bisch Paulo M, Fehrentz Jean-Alain, Catoire Laurent J, Floquet Nicolas, Banères Jean-Louis

Abstract excerpt

The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here we demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects. We find that PIP2 shifts the conformational equilibrium of GHSR away from its inactive state, favoring basal and agonist-induced G protein activation. This occurs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine
Share to Fluorescence Resonance Energy Transfer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Allosteric Regulation

Share to Lipid Bilayers

Share to Lipid Metabolism

Share to Lipids

Share to Phosphatidylinositol 4,5-Diphosphate

Share to Receptors, Ghrelin

Source

Open in PubMed Open full text

Identifiers

PMID: 34168117
DOI: 10.1038/s41467-021-23756-y
PMCID: PMC8225672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allosteric modulation of ghrelin receptor signaling by lipids.PMID 34168117Read ↗

Beyond Hunger: The Structure, Signaling, and Systemic Roles of Ghrelin.Semantic proximity Read ↗

Beyond Hunger: Structure, Signaling and Systemic Roles of GhrelinSemantic proximity Read ↗

Rare variant in intracellular loop-2 of the ghrelin receptor reveals novel mechanisms of GPCR biased signaling and traffickingSemantic proximity Read ↗

Molecular regulation of GPCR-G-protein-governed PIP3 generation and its adaptationSemantic proximity Read ↗

Membrane interactions of G proteins and other related proteins.Semantic proximity Read ↗

Molecular mechanism of agonism and inverse agonism in ghrelin receptor.Semantic proximity Read ↗

Four missense mutations in the ghrelin receptor result in distinct pharmacological abnormalities.Semantic proximity Read ↗

Distinct glycerophospholipids potentiate Gsα-activated adenylyl cyclase activitySemantic proximity Read ↗

Free Fatty Acid Receptor 2 Allosterism is Defined By Cellular ContextSemantic proximity Read ↗

The Complex World of Regulation of Pituitary Growth Hormone Secretion: The Role of Ghrelin, Klotho, and Nesfatins in It.Semantic proximity Read ↗

A non-canonical mechanism of GPCR activation.Semantic proximity Read ↗

Translating biased signaling in the ghrelin receptor system into differential in vivo functionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.