Article
A non-canonical mechanism of GPCR activation.
Nature communications - 16 Nov 2024
Powers Alexander S, Khan Aasma, Paggi Joseph M, Latorraca Naomi R, Souza Sarah, Di Salvo Jerry, Lu Jun, Soisson Stephen M, Johnston Jennifer M, Weinglass Adam B, Dror Ron O
Abstract excerpt
The goal of designing safer, more effective drugs has led to tremendous interest in molecular mechanisms through which ligands can precisely manipulate the signaling of G-protein-coupled receptors (GPCRs), the largest class of drug targets. Decades of research have led to the widely accepted view that all agonists-ligands that trigger GPCR activation-function by causing rearrangement of the GPCR's transmembrane...
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