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Article

Molecular mechanism of agonism and inverse agonism in ghrelin receptor.

Nature communications - 13 Jan 2022

Qin Jiao, Cai Ye, Xu Zheng, Ming Qianqian, Ji Su-Yu, Wu Chao, Zhang Huibing, Mao Chunyou, Shen Dan-Dan, Hirata Kunio, Ma Yanbin, Yan Wei, Zhang Yan, Shao Zhenhua

Abstract excerpt

Much effort has been invested in the investigation of the structural basis of G protein-coupled receptors (GPCRs) activation. Inverse agonists, which can inhibit GPCRs with constitutive activity, are considered useful therapeutic agents, but the molecular mechanism of such ligands remains insufficiently understood. Here, we report a crystal structure of the ghrelin receptor bound to the inverse agonist...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35027551
DOI: 10.1038/s41467-022-27975-9
PMCID: PMC8758724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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