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Article

Four missense mutations in the ghrelin receptor result in distinct pharmacological abnormalities.

The Journal of pharmacology and experimental therapeutics - 1 Sept 2007

Liu Guang, Fortin Jean-Philippe, Beinborn Martin, Kopin Alan S

Abstract excerpt

The growth hormone secretagogue receptor (GHSR) plays an important role in regulating food intake and energy homeostasis. In this study, we compared the pharmacological properties of four reported variants of the human GHSR (I134T, V160M, A204E, and F279L) with those of the wild-type receptor. Corresponding recombinant receptors were transiently expressed in either human embryonic kidney 293 or COS-7 cells. Basal...

Read the complete abstract on PubMed

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Share to Genetic Variation
Share to Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Protein Transport

Share to Receptors, G-Protein-Coupled

Share to Receptors, Ghrelin

Share to Signal Transduction

Source

Identifiers

PMID: 17596538
DOI: 10.1124/jpet.107.123141

Genes

GHSR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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