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Article

Beyond Hunger: Structure, Signaling and Systemic Roles of Ghrelin

2025-10-06

Abstract excerpt

Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor 1a (GHSR1a), has expanded from a “hunger hormone” to a pleiotropic regulator of whole-body physiology. This review synthesizes current advances spanning ghrelin biogenesis, signaling, and systems biology. Physiologically, preproghrelin processing and O-acylation by ghrelin O-acyltransferase (GOAT) generate acyl-ghrelin, the high-potency GHS...

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Literature Corpus work
0346e342-0f68-5785-b3e0-582445b2f106
DOI
10.20944/preprints202510.0358.v1
Open publication

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Beyond Hunger: Structure, Signaling and Systemic Roles of GhrelinDOI 10.20944/preprints202510.0358.v1
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