Article

Distinct glycerophospholipids potentiate Gsα-activated adenylyl cyclase activity

2022-02-24

Abstract excerpt

Nine mammalian adenylyl cyclases (AC) are pseudoheterodimers with two hexahelical membrane domains which are isoform-specifically conserved. Previously we proposed that these membrane domains are orphan receptors (10.7554/eLife.13098; 10.1016/j.cellsig.2020.109538). Lipids extracted from fetal bovine serum at pH 1 inhibited several mAC activities. Guided by a lipidomic analysis we tested glycerophospholipids as po...

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Literature Corpus work: 0bd38c28-0304-52f9-8a22-6ccabbbb2f0b
DOI: 10.1101/2022.02.23.481604

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