Article

Free Fatty Acid Receptor 2 Allosterism is Defined By Cellular Context

2025-12-19

Abstract excerpt

<h4>Background</h4> Allosteric modulators offer a way to fine-tune GPCR signaling in the presence of endogenous ligands. The short-chain fatty acid receptor FFA2R (GPR43) recognizes propionate and allosteric ligands such as Cmp58 and AZ1729. We characterized FFA2R signaling and allosteric modulation using multiple cell models including HEK293, HL60 cells and primary human neutrophils. <h4>Methods</h4> FFA2R acti...

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Literature Corpus work: d5b7d4be-6801-539a-ad8b-6c900ab9c6bb
DOI: 10.64898/2025.12.18.695082

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