Article

Molecular regulation of GPCR-G-protein-governed PIP3 generation and its adaptation

2022-09-01

Abstract excerpt

Phosphatidylinositol (3,4,5) trisphosphate (PIP3) is a plasma membrane-bound signaling phospholipid involved in many cellular signaling pathways that control crucial cellular processes and behaviors, including cytoskeleton remodeling, metabolism, chemotaxis, and apoptosis. Therefore, defective PIP3 signaling is implicated in various disease driving processes, including cancer metastasis, diabetes, obesity, and car...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d7ce62d8-7f51-545b-b347-2b952378ec1f
DOI: 10.1101/2022.08.31.506078

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular regulation of GPCR-G-protein-governed PIP3 generation and its adaptationDOI 10.1101/2022.08.31.506078Read

The cell biology behind the oncogenic PIP3 lipidsSemantic proximity Read

The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signallingSemantic proximity Read

Role of Phosphoinositides in Cellular Signaling, Functions and DiseasesSemantic proximity Read

Allosteric modulation of ghrelin receptor signaling by lipids.Semantic proximity Read

PI3K isoforms in cell signalling and vesicle traffickingSemantic proximity Read

The emerging mechanisms of isoform-specific PI3K signalling.Semantic proximity Read

Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependentSemantic proximity Read

Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variantSemantic proximity Read

[Protein G heterotrimerics: role in normal and pathological transduction].Semantic proximity Read

Control of T lymphocyte fate decisions by PI3K signalingSemantic proximity Read

Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membraneSemantic proximity Read

PI(3,5)P <sub>2</sub> Controls the Signaling Activity of Class I PI3KSemantic proximity Read