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Article

Beyond Hunger: The Structure, Signaling, and Systemic Roles of Ghrelin.

International journal of molecular sciences - 13 Nov 2025

Polishchuk Hlafira, Guzik Krzysztof, Kantyka Tomasz

Abstract excerpt

Our understanding of Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor 1a (GHSR1a), has expanded from considering it to be a "hunger hormone" to a pleiotropic regulator of whole-body physiology. This review synthesizes the current advances spanning ghrelin biogenesis, signaling, and systems biology. Physiologically, preproghrelin processing and O-acylation by ghrelin O-acyltransferase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41303478
DOI: 10.3390/ijms262210996
PMCID: PMC12651995

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