Article

Rare variant in intracellular loop-2 of the ghrelin receptor reveals novel mechanisms of GPCR biased signaling and trafficking

2025-03-13

Abstract excerpt

<h4>ABSTRACT</h4> G protein-coupled receptors (GPCRs) are the largest class of integral membrane proteins and the most common pharmaceutical drug target. Through allosteric coupling, GPCRs transduce extracellular stimuli into physiologically-relevant intracellular signaling cascades via G proteins and β-arrestin (βarr). The growth hormone secretagogue receptor (GHSR) is a rhodopsin-like, peptide hormone GPCR cons...

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Literature Corpus work: 04085cd3-4d5c-58f7-957c-32ae127aef21
DOI: 10.1101/2025.03.11.642421

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