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Article

Proteasomal conformation controls unfolding ability.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2021

Cresti Julianna R, Manfredonia Abramo J, Bragança Christopher E, Boscia Joseph A, Hurley Christina M, Cundiff Mary D, Kraut Daniel A

Abstract excerpt

The 26S proteasome is the macromolecular machine responsible for the bulk of protein degradation in eukaryotic cells. As it degrades a ubiquitinated protein, the proteasome transitions from a substrate-accepting conformation (s1) to a set of substrate-processing conformations (s3 like), each stabilized by different intramolecular contacts. Tools to study these conformational changes remain limited, and although...

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Identifiers

PMID: 34161281
DOI: 10.1073/pnas.2101004118
PMCID: PMC8237680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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