Article

Visualizing ATP-dependent substrate-processing dynamics of the human 26S proteasome at near-atomic resolution

2018-09-16

Abstract excerpt

The proteasome is an ATP-dependent 2.5-megadalton machine responsible for ubiquitylated protein degradation in all eukaryotic cells. Here we present cryo-EM structures of the substrate-engaged human 26S proteasome in seven conformational states at 2.8-3.6 Å resolution, captured during polyubiquitylated protein degradation. These structures visualize a continuum of dynamic substrate-proteasome interactions from ubi...

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Literature Corpus work: ef96de6d-9c38-51dd-88ce-7cc5f3ddbd3a
DOI: 10.1101/419051

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