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Article

The importance of proteasome grip depends on substrate stability.

Biochemical and biophysical research communications - 15 Oct 2023

Stanton Destini A, Ellis Emily A, Cruse Mariah R, Jedlinski Rafael, Kraut Daniel A

Abstract excerpt

The 26S proteasome is responsible for the unfolding and degradation of intracellular proteins in eukaryotes. A hexameric ring of ATPases (Rpt1-Rpt6) grabs onto substrates and unfolds them by pulling them through a central pore and translocating them into the 20S degradation chamber. A set of pore loops containing a so-called aromatic paddle motif in each Rpt subunit is believed to be important for the...

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PMID: 37591185
DOI: 10.1016/j.bbrc.2023.08.025

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