Article
Glycine-alanine repeats impair proper substrate unfolding by the proteasome.
The EMBO journal - 19 Apr 2006
Hoyt Martin A, Zich Judith, Takeuchi Junko, Zhang Mingsheng, Govaerts Cedric, Coffino Philip
Abstract excerpt
Proteasome ATPases unravel folded proteins. Introducing a sequence containing only glycine and alanine residues (GAr) into substrates can impair their digestion. We previously proposed that a GAr interferes with the unfolding capacity of the proteasome, leading to partial degradation of products. Here we tested that idea in several ways. Stabilizing or destabilizing a folded domain within substrate proteins...
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