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Article

Fluorescence Turn-On Folding Sensor To Monitor Proteome Stress in Live Cells.

Journal of the American Chemical Society - 9 Sept 2015

Liu Yu, Zhang Xin, Chen Wentao, Tan Yun Lei, Kelly Jeffery W

Abstract excerpt

Proteome misfolding and/or aggregation, caused by a thermal perturbation or a related stress, transiently challenges the cellular protein homeostasis (proteostasis) network capacity of cells by consuming chaperone/chaperonin pathway and degradation pathway capacity. Developing protein client-based probes to quantify the cellular proteostasis network capacity in real time is highly desirable. Herein we introduce a...

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Identifiers

PMID: 26305239
DOI: 10.1021/jacs.5b04366
PMCID: PMC4755273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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