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Article

Rotamer strain as a determinant of protein structural specificity.

Protein science : a publication of the Protein Society - 1 Dec 1999

Lazar G A, Johnson E C, Desjarlais J R, Handel T M

Abstract excerpt

We present direct evidence for a change in protein structural specificity due to hydrophobic core packing. High resolution structural analysis of a designed core variant of ubiquitin reveals that the protein is in slow exchange between two conformations. Examination of side-chain rotamers indicates that this dynamic response and the lower stability of the protein are coupled to greater strain and mobility in the...

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Identifiers

PMID: 10631975
DOI: 10.1110/ps.8.12.2598
PMCID: PMC2144231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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