Article
Observing a late folding intermediate of Ubiquitin at atomic resolution by NMR.
Protein science : a publication of the Protein Society - 1 Aug 2016
Surana Parag, Das Ranabir
Abstract excerpt
The study of intermediates in the protein folding pathway provides a wealth of information about the energy landscape. The intermediates also frequently initiate pathogenic fibril formations. While observing the intermediates is difficult due to their transient nature, extreme conditions can partially unfold the proteins and provide a glimpse of the intermediate states. Here, we observe the high resolution...
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