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Cohesin Mutations in Myeloid Malignancies.

Trends in cancer - 1 Apr 2017

Fisher Joseph B, McNulty Maureen, Burke Michael J, Crispino John D, Rao Sridhar

Abstract excerpt

Acute Myeloid Leukemia (AML) is a hematologic malignancy with a poor prognosis. Recent genome-wide sequencing studies have identified frequent mutations in genes encoding members of the cohesin complex. Mutations in cohesin contribute to myeloid malignancies by conferring enhanced self-renewal of hematopoietic stem and progenitor cells but the mechanisms behind this phenotype have not been fully elucidated. Of...

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Acute Myeloid Leukemia Research
Cancer Genomics and Diagnostics
Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
Cohesins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genomics and Chromatin Dynamics

Leukemia, Myeloid, Acute

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Identifiers

PMID: 28626802
DOI: 10.1016/j.trecan.2017.02.006
PMCID: PMC5472227

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