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Article

Cohesin gene mutations in tumorigenesis: from discovery to clinical significance.

BMB reports - 1 Jun 2014

Solomon David A, Kim Jung-Sik, Waldman Todd

Abstract excerpt

Cohesin is a multi-protein complex composed of four core subunits (SMC1A, SMC3, RAD21, and either STAG1 or STAG2) that is responsible for the cohesion of sister chromatids following DNA replication until its cleavage during mitosis thereby enabling faithful segregation of sister chromatids into two daughter cells. Recent cancer genomics analyses have discovered a high frequency of somatic mutations in the genes...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24856830
DOI: 10.5483/bmbrep.2014.47.6.092
PMCID: PMC4163871

Genes

ESPL1
NIPBL
RAD21
SMC3
STAG1
STAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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