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Article

PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA

16 Jun 2021

Abstract excerpt

Alteration of RNA splicing is a hallmark of cellular senescence, which is associated with age-related disease and cancer development. However, the roles of splicing factors in cellular senescence are not fully understood. In this study, we identified the splicing factor PRPF19 as a critical regulator of cellular senescence in normal human diploid fibroblasts. PRPF19 was downregulated during replicative...

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PMID: 34144037
DOI: 10.1016/j.jbc.2021.100882

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