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Article

Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors.

Molecular cell - 15 Mar 2018

de Moura Tales Rocha, Mozaffari-Jovin Sina, Szabó Csaba Zoltán Kibédi, Schmitzová Jana, Dybkov Olexandr, Cretu Constantin, Kachala Michael, Svergun Dmitri, Urlaub Henning, Lührmann Reinhard, Pena Vladimir

Abstract excerpt

Human nineteen complex (NTC) acts as a multimeric E3 ubiquitin ligase in DNA repair and splicing. The transfer of ubiquitin is mediated by Prp19-a homotetrameric component of NTC whose elongated coiled coils serve as an assembly axis for two other proteins called SPF27 and CDC5L. We find that Prp19 is inactive on its own and have elucidated the structural basis of its autoinhibition by crystallography and...

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Identifiers

PMID: 29547724
DOI: 10.1016/j.molcel.2018.02.022

Genes

PLRG1

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