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Identification of miR‐494 direct targets involved in senescence of human diploid fibroblasts

13 May 2014

Abstract excerpt

Cellular senescence is a permanent cell cycle arrest triggered by different stimuli. We recently identified up-regulation of microRNA (miR)-494 as a component of the genetic program leading to senescence of human diploid IMR90 fibroblasts. Here, we used 2-dimensional differential gel electrophoresis (2D-DIGE) coupled to mass spectrometry to profile protein expression changes induced by adoptive overexpression of...

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Share to Advanced biosensing and bioanalysis techniques
Share to MicroRNA in disease regulation
Share to Telomeres, Telomerase, and Senescence

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PMID: 24823364
DOI: 10.1096/fj.13-239129

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