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Article

Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing.

Autophagy - 1 Jan 2018

Xu Guang, Li Ting, Chen Jiayi, Li Changyan, Zhao Haixin, Yao Chengcheng, Dong Hua, Wen Kaiqing, Wang Kai, Zhao Jie, Xia Qing, Zhou Tao, Zhang Huafeng, Gao Ping, Li Ailing, Pan Xin

Abstract excerpt

Aged and damaged mitochondria can be selectively degraded by specific autophagic elimination, termed mitophagy. Defects in mitophagy have been increasingly linked to several diseases including neurodegenerative diseases, metabolic diseases and other aging-related diseases. However, the molecular mechanisms of mitophagy are not fully understood. Here, we identify PRPF8 (pre-mRNA processing factor 8), a core...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30103670
DOI: 10.1080/15548627.2018.1501251
PMCID: PMC6135625

Genes

PRPF8
ULK1
PRPF31
PRPF6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing.PMID 30103670Read ↗

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