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Article

Identification of nonsense-mediated mRNA decay pathway as a critical regulator of p53 isoform β

7 Dec 2017

Abstract excerpt

Human TP53 gene encodes the tumor suppressor p53 and, via alternative splicing, the p53β and γ isoforms. Numerous studies have shown that p53β/γ can modulate p53 functions and are critically involved in regulation of cellular response to stress conditions. However, it is not fully understood how the β and γ isoforms are regulated following splicing. Using gene targeting and RNAi, we showed that depletion of the...

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PMID: 29235495
DOI: 10.1038/s41598-017-17283-4

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