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Article

DNA-Damage-Induced Alternative Splicing of p53

12 Jan 2021

Abstract excerpt

Cellular responses to DNA damage and other stresses are important determinants of mutagenesis and impact the development of a wide range of human diseases. TP53 is highly mutated in human cancers and plays an essential role in stress responses and cell fate determination. A central dogma of p53 induction after DNA damage has been that the induction results from a transient increase in the half-life of the p53...

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PMID: 33445417
DOI: 10.3390/cancers13020251

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