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Article

Error-Prone Splicing Controlled by the Ubiquitin Relative Hub1.

Molecular cell - 3 Aug 2017

Karaduman Ramazan, Chanarat Sittinan, Pfander Boris, Jentsch Stefan

Abstract excerpt

Accurate pre-mRNA splicing is needed for correct gene expression and relies on faithful splice site recognition. Here, we show that the ubiquitin-like protein Hub1 binds to the DEAD-box helicase Prp5, a key regulator of early spliceosome assembly, and stimulates its ATPase activity thereby enhancing splicing and relaxing fidelity. High Hub1 levels enhance splicing efficiency but also cause missplicing by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28712727
DOI: 10.1016/j.molcel.2017.06.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel mechanism for Prp5 function in prespliceosome formation and proofreading the branch site sequence.Semantic proximity Read ↗

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