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Article

CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation.

Nature communications - 17 Jun 2021

Zabrady Katerina, Zabrady Matej, Kolesar Peter, Li Arthur W H, Doherty Aidan J

Abstract excerpt

CRISPR-Cas pathways provide prokaryotes with acquired "immunity" against foreign genetic elements, including phages and plasmids. Although many of the proteins associated with CRISPR-Cas mechanisms are characterized, some requisite enzymes remain elusive. Genetic studies have implicated host DNA polymerases in some CRISPR-Cas systems but CRISPR-specific replicases have not yet been discovered. We have identified...

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Identifiers

PMID: 34140468
DOI: 10.1038/s41467-021-23535-9
PMCID: PMC8211822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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