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Article

The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence

27 Jan 2021

Abstract excerpt

Cells and organisms have a wide range of mechanisms to defend against infection by viruses and other mobile genetic elements (MGE). Type III CRISPR systems detect foreign RNA and typically generate cyclic oligoadenylate (cOA) second messengers that bind to ancillary proteins with CARF (CRISPR associated Rossman fold) domains. This results in the activation of fused effector domains for antiviral defence. The best...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33590098
DOI: 10.1093/nar/gkab073

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