Article

END nucleases: Antiphage defense systems targeting multiple hypermodified phage genomes

2025-03-31

Abstract excerpt

Prokaryotes carry clusters of phage defense systems in “defense islands” that have been extensively exploited bioinformatically and experimentally for discovery of immune functions. However, little effort has been dedicated to determining which specific system(s) within defense islands limit lytic phage reproduction in clinical bacterial strains. Here, we employed the CRISPR-based Cascade-Cas3 system to delete def...

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Literature Corpus work: 95b19ff5-70f0-5d84-8299-773f4a4d00c6
DOI: 10.1101/2025.03.31.646159

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