Article

Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers <i>in trans</i>

2023-06-23

Abstract excerpt

<h4>ABSTRACT</h4> Type IV-A CRISPR-Cas systems are primarily encoded on plasmids and form multi-subunit ribonucleoprotein complexes with unknown biological functions. In contrast to other CRISPR-Cas types, they lack the archetypical CRISPR acquisition module and encode a DinG helicase instead of a nuclease component. Type IV-A3 systems are carried by large conjugative plasmids that often harbor multiple antibioti...

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Literature Corpus work: a453eb38-cc06-59a3-ba0b-ed0aaae29d7f
DOI: 10.1101/2023.06.23.546257

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