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CBASS phage defense and evolution of antiviral nucleotide signaling

1 Feb 2022

Abstract excerpt

Cyclic oligonucleotide-based antiphage signaling system (CBASS) immunity is a widespread form of antiphage defense in bacteria and archaea. Each CBASS operon encodes a cGAS/DncV-like Nucleotidyltransferase (CD-NTase) enzyme that synthesizes a nucleotide second messenger in response to viral infection. An associated Cap effector protein then binds the nucleotide signal and executes cell death to destroy the host...

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PMID: 35123147
DOI: 10.1016/j.coi.2022.01.002

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