Article
A CRISPR-associated factor Csa3a regulates DNA damage repair in Crenarchaeon Sulfolobus islandicus.
Nucleic acids research - 25 Sept 2020
Liu Zhenzhen, Sun Mengmeng, Liu Jilin, Liu Tao, Ye Qing, Li Yingjun, Peng Nan
Abstract excerpt
CRISPR-Cas system provides acquired immunity against invasive genetic elements in prokaryotes. In both bacteria and archaea, transcriptional factors play important roles in regulation of CRISPR adaptation and interference. In the model Crenarchaeon Sulfolobus islandicus, a CRISPR-associated factor Csa3a triggers CRISPR adaptation and activates CRISPR RNA transcription for the immunity. However, regulation of DNA...
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