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Article

CRISPR interference and priming varies with individual spacer sequences.

Nucleic acids research - 15 Dec 2015

Xue Chaoyou, Seetharam Arun S, Musharova Olga, Severinov Konstantin, Brouns Stan J J, Severin Andrew J, Sashital Dipali G

Abstract excerpt

CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) systems allow bacteria to adapt to infection by acquiring 'spacer' sequences from invader DNA into genomic CRISPR loci. Cas proteins use RNAs derived from these loci to target cognate sequences for destruction through CRISPR interference. Mutations in the protospacer adjacent motif (PAM) and seed regions block interference...

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Share to Clustered Regularly Interspaced Short Palindromic Repeats
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Source

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Identifiers

PMID: 26586800
DOI: 10.1093/nar/gkv1259
PMCID: PMC4678831

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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