Article
CRISPR provides acquired resistance against viruses in prokaryotes.
Science (New York, N.Y.) - 23 Mar 2007
Barrangou Rodolphe, Fremaux Christophe, Deveau Hélène, Richards Melissa, Boyaval Patrick, Moineau Sylvain, Romero Dennis A, Horvath Philippe
Abstract excerpt
Clustered regularly interspaced short palindromic repeats (CRISPR) are a distinctive feature of the genomes of most Bacteria and Archaea and are thought to be involved in resistance to bacteriophages. We found that, after viral challenge, bacteria integrated new spacers derived from phage genomic sequences. Removal or addition of particular spacers modified the phage-resistance phenotype of the cell. Thus,...
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