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Discovery and Features of an Alkylating Signature in Colorectal Cancer

17 Jun 2021

Abstract excerpt

Abstract Several risk factors have been established for colorectal cancer, yet their direct mutagenic effects in patients' tumors remain to be elucidated. Here, we leveraged whole-exome sequencing data from 900 colorectal cancer cases that had occurred in three U.S.-wide prospective studies with extensive dietary and lifestyle information. We found an alkylating signature that was previously undescribed in...

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PMID: 34140290
DOI: 10.1158/2159-8290.cd-20-1656

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