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Article

Germline Predisposition to Oncogenic Alkylating Damage in Colorectal Cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Mar 2026

Gurjao Carino, Cazaubiel Jules, Tan Chichun, Reardon Brendan, Hofree Matan, Ugai Tomotaka, Meyerhardt Jeffrey A, Nowak Jonathan A, Giovannucci Edward, Townsend Jeffrey P, Ogino Shuji, Giannakis Marios

Abstract excerpt

BACKGROUND: Red meat consumption is a risk factor for colorectal cancer and has been linked to tumor alkylating DNA damage. rs16906252-T is a cis expression quantitative trait locus variant associated with silencing of MGMT, a central alkylating damage repair gene. We hypothesize that rs16906252-T carriers are predisposed to alkylating damage mutations. METHODS: We conducted mutational signature deconvolution of...

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Source

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Identifiers

PMID: 41416871
DOI: 10.1158/1055-9965.EPI-25-1006
PMCID: PMC12977196

Genes

MGMT
NHS
IMPACT
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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