Article
Identification and validation of a previously missed mutational signature in colorectal cancer.
Nature communications - 12 Aug 2026
Kazachkova Mariya, Otlu Burçak, Díaz-Gay Marcos, Abbasi Ammal, Moody Sarah, Jiang Zichen, Perdomo Sandra, Wedge David C, Brennan Paul, Stratton Michael R, Alexandrov Ludmil B
Abstract excerpt
Mutational signature analysis has enhanced our understanding of mutagenic processes. In a recent study, we analyzed 802 microsatellite-stable colorectal cancers (CRC) and identified a de novo signature, SBS_D, which was decomposed into SBS18. Here, we re-evaluate this decomposition and provide evidence that SBS_D represents a distinct mutational process from SBS18. Through an analysis of 2,616 CRCs across three...
Read the complete abstract on PubMedTopics
- Colorectal Neoplasms
- Humans
- Mutation
- DNA Repair
- DNA Mutational Analysis
- Microsatellite Repeats