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Article

Why Is Colorectal Cancer Occurring Earlier? Metabolic Dysfunction, Underrecognized Carcinogens, and Emerging Controversies.

Current obesity reports - 20 Mar 2026

Dalamaga Maria, Rozani Sofia, Petropoulou Dimitra

Abstract excerpt

PURPOSE OF THE REVIEW: Early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before 50 years of age, is increasing worldwide and represents a major challenge to current prevention and screening paradigms. While obesity and metabolic dysfunction are important contributors, EOCRC appears to arise from a complex interplay of genetic susceptibility, metabolic stress, early-life exposures,...

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Identifiers

PMID: 41857189
DOI: 10.1007/s13679-026-00700-z
PMCID: PMC13002696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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