Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lifetime alcohol intake is associated with an increased risk of KRAS+ and BRAF-/KRAS- but not BRAF+ colorectal cancer.

International journal of cancer - 1 Apr 2017

Jayasekara Harindra, MacInnis Robert J, Williamson Elizabeth J, Hodge Allison M, Clendenning Mark, Rosty Christophe, Walters Rhiannon, Room Robin, Southey Melissa C, Jenkins Mark A, Milne Roger L, Hopper John L, Giles Graham G, Buchanan Daniel D, English Dallas R

Abstract excerpt

Ethanol in alcoholic beverages is a causative agent for colorectal cancer. Colorectal cancer is a biologically heterogeneous disease, and molecular subtypes defined by the presence of somatic mutations in BRAF and KRAS are known to exist. We examined associations between lifetime alcohol intake and molecular and anatomic subtypes of colorectal cancer. We calculated usual alcohol intake for 10-year periods from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Alcohol Drinking

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alcoholism

Share to Anthropometry

Share to Carcinoma

Share to Genes, ras

Share to Proto-Oncogene Proteins p21(ras)

Share to Surveys and Questionnaires

Source

Identifiers

PMID: 27943267
DOI: 10.1002/ijc.30568

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lifetime alcohol intake is associated with an increased risk of KRAS+ and BRAF-/KRAS- but not BRAF+ colorectal cancer.PMID 27943267Read ↗

Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathwaysSemantic proximity Read ↗

Alcohol and colorectal cancer risk, subclassified by mutational signatures of DNA mismatch repair deficiency.Semantic proximity Read ↗

Molecular Mechanisms of Alcohol-Induced Colorectal CarcinogenesisSemantic proximity Read ↗

Alcohol consumption and molecular subtypes of colorectal cancer: pooled observational and Mendelian randomization analyses.Semantic proximity Read ↗

Association between KRAS mutation and alcohol consumption in Brazilian patients with colorectal cancer.Semantic proximity Read ↗

Discovery and Features of an Alkylating Signature in Colorectal CancerSemantic proximity Read ↗

Colorectal cancer risk in bowel adenomas based on lifestyle exposures, tissue preconditioning and DNA methylationSemantic proximity Read ↗

Risk Factors and Incidence of Colorectal Cancer According to Major Molecular Subtypes.Semantic proximity Read ↗

Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.Semantic proximity Read ↗

Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women.Semantic proximity Read ↗

Colonoscopy and Reduction of Colorectal Cancer Risk by Molecular Tumor Subtypes: A Population-Based Case-Control Study.Semantic proximity Read ↗

Association Between Smoking and Molecular Subtypes of Colorectal Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.