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Article

Alcohol and colorectal cancer risk, subclassified by mutational signatures of DNA mismatch repair deficiency.

Journal of the National Cancer Institute - 1 Aug 2024

Fang Aiping, Ugai Tomotaka, Gurjao Carino, Zhong Rong, Liu Zhenhua, Zhang Xinyuan, Wang Peilu, Nowak Jonathan, Wang Molin, Giannakis Marios, Ogino Shuji, Zhang Xuehong, Giovannucci Edward

Abstract excerpt

BACKGROUND: We examined whether the association between alcohol consumption and colorectal cancer (CRC) incidence was stronger for tumors with higher contributions of defective mismatch repair (dMMR)-related tumor mutational signatures. METHODS: We used data from 227 916 men and women who participated in the Nurses' Health Study (1980-2016), the Nurses' Health Study II (1991-2017), and the Health Professionals...

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Identifiers

PMID: 38574386
DOI: 10.1093/jnci/djae078
PMCID: PMC11308185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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