Article

Germline predisposition to oncogenic alkylating damage in colorectal cancer

2025-07-02

Abstract excerpt

<h4>Background</h4> Red meat consumption is a risk factor for colorectal cancer (CRC) and has been linked to tumor alkylating DNA damage. rs16906252 -T is a cis expression quantitative trait locus (eQTL) variant associated with silencing of MGMT , a central alkylating damage repair gene. We hypothesize that rs16906252 -T carriers are predisposed to alkylating damage mutations. <h4>Methods</h4> We conducted mutat...

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Literature Corpus work: aace77db-c417-5fbb-b36b-50ab2c279494
DOI: 10.1101/2025.06.30.25330572

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