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Article

Elevated HIV Infection of CD4 T Cells in MRKAd5 Vaccine Recipients Due to CD8 T Cells Targeting Adapted Epitopes.

Journal of virology - 26 Jul 2021

Qin Kai, Boppana Sushma, Carlson Jonathan M, Fiore-Gartland Andrew, Files Jacob, Zeng Jie, Edberg Jeffrey, Mailliard Robbie B, Ochsenbauer Christina, Bansal Anju, Goepfert Paul

Abstract excerpt

HIV frequently escapes CD8 T cell responses, leading to the accumulation of viral adaptations. We recently demonstrated that during chronic HIV infection, adapted epitopes can promote maturation of dendritic cells (DCs) through direct CD8 T cell interactions and lead to enhanced HIV trans-infection of CD4 T cells. Here, we sought to determine the role of such adaptations following HIV MRKAd5 vaccination. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34076482
DOI: 10.1128/JVI.00160-21
PMCID: PMC8312883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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