Article
Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.
PloS one - 1 Jan 2017
Borthwick Nicola, Lin Zhansong, Akahoshi Tomohiro, Llano Anuska, Silva-Arrieta Sandra, Ahmed Tina, Dorrell Lucy, Brander Christian, Murakoshi Hayato, Takiguchi Masafumi, Hanke Tomáš
Abstract excerpt
BACKGROUND: Fine definition of targeted CD8+ T-cell epitopes and their human leucocyte antigen (HLA) class I restriction informs iterative improvements of HIV-1 T-cell vaccine designs and may predict early vaccine success or failure. Here, lymphocytes from volunteers, who had received candidate HIVconsv vaccines expressing conserved sub-protein regions of HIV-1, were used to define the optimum-length target...
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