Article
Vaccine-induced gag-specific T cells are associated with reduced viremia after HIV-1 infection.
The Journal of infectious diseases - 15 Oct 2013
Janes Holly, Friedrich David P, Krambrink Amy, Smith Rebecca J, Kallas Esper G, Horton Helen, Casimiro Danilo R, Carrington Mary, Geraghty Daniel E, Gilbert Peter B, McElrath M Juliana, Frahm Nicole
Abstract excerpt
The contribution of host T-cell immunity and HLA class I alleles to the control of human immunodeficiency virus (HIV-1) replication in natural infection is widely recognized. We assessed whether vaccine-induced T-cell immunity, or expression of certain HLA alleles, impacted HIV-1 control after infection in the Step MRKAd5/HIV-1 gag/pol/nef study. Vaccine-induced T cells were associated with reduced plasma...
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