A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells.

doi:10.1016/j.immuni.2012.11.021

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells.

Immunity - 21 Mar 2013

Ladell Kristin, Hashimoto Masao, Iglesias Maria Candela, Wilmann Pascal G, McLaren James E, Gras Stéphanie, Chikata Takayuki, Kuse Nozomi, Fastenackels Solène, Gostick Emma, Bridgeman John S, Venturi Vanessa, Arkoub Zaïna Aït, Agut Henri, van Bockel David J, Almeida Jorge R, Douek Daniel C, Meyer Laurence, Venet Alain, Takiguchi Masafumi, Rossjohn Jamie, Price David A, Appay Victor

Abstract excerpt

The capacity of the immune system to adapt to rapidly evolving viruses is a primary feature of effective immunity, yet its molecular basis is unclear. Here, we investigated protective HIV-1-specific CD8+ T cell responses directed against the immunodominant p24 Gag-derived epitope KK10 (KRWIILGLNK263-272) presented by human leukocyte antigen (HLA)-B∗2705. We found that cross-reactive CD8+ T cell clonotypes were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen Presentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Clone Cells

Share to Epitopes, T-Lymphocyte

Share to HIV Core Protein p24

Share to HLA-B27 Antigen

Share to Immunodominant Epitopes

Share to Receptors, Antigen, T-Cell

Source

Open in PubMed

Identifiers

PMID: 23521884
DOI: 10.1016/j.immuni.2012.11.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells.PMID 23521884Read ↗

HIV-specific T cells: strategies for fighting a moving target.Semantic proximity Read ↗

De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

The flexibility of the TCR allows recognition of a large set of naturally occurring epitope variants by HIV-specific cytotoxic T lymphocytes.Semantic proximity Read ↗

Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response.Semantic proximity Read ↗

Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.Semantic proximity Read ↗

HIV-1 Mutants that Escape the Cytotoxic T-Lymphocytes are Defective in Viral DNA IntegrationSemantic proximity Read ↗

In vivo priming of HIV-specific CTLs determines selective cross-reactive immune responses against poorly immunogenic HIV-natural variants.Semantic proximity Read ↗

Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral AntigensSemantic proximity Read ↗

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.Semantic proximity Read ↗

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells.Semantic proximity Read ↗

Duration of Initial Viremia Modulates Functional Properties of HIV-specific T Cell ReceptorsSemantic proximity Read ↗

The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.