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Article

MRKAd5 HIV-1 Gag/Pol/Nef vaccine-induced T-cell responses inadequately predict distance of breakthrough HIV-1 sequences to the vaccine or viral load.

PloS one - 1 Jan 2012

Janes Holly, Frahm Nicole, DeCamp Allan, Rolland Morgane, Gabriel Erin, Wolfson Julian, Hertz Tomer, Kallas Esper, Goepfert Paul, Friedrich David P, Corey Lawrence, Mullins James I, McElrath M Juliana, Gilbert Peter

Abstract excerpt

BACKGROUND: The sieve analysis for the Step trial found evidence that breakthrough HIV-1 sequences for MRKAd5/HIV-1 Gag/Pol/Nef vaccine recipients were more divergent from the vaccine insert than placebo sequences in regions with predicted epitopes. We linked the viral sequence data with immune response and acute viral load data to explore mechanisms for and consequences of the observed sieve effect. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to gag Gene Products, Human Immunodeficiency Virus

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Share to nef Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 22952672
DOI: 10.1371/journal.pone.0043396
PMCID: PMC3428369

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