Article
Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1.
Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2009
Benlahrech Adel, Harris Julian, Meiser Andrea, Papagatsias Timos, Hornig Julia, Hayes Peter, Lieber Andre, Athanasopoulos Takis, Bachy Veronique, Csomor Eszter, Daniels Rod, Fisher Kerry, Gotch Frances, Seymour Len, Logan Karen, Barbagallo Romina, Klavinskis Linda, Dickson George, Patterson Steven
Abstract excerpt
In the recently halted HIV type 1 (HIV-1) vaccine STEP trial, individuals that were seropositive for adenovirus serotype 5 (Ad5) showed increased rates of HIV-1 infection on vaccination with an Ad5 vaccine. We propose that this was due to activation and expansion of Ad5-specific mucosal-homing memory CD4 T cells. To test this hypothesis, Ad5 and Ad11 antibody titers were measured in 20 healthy volunteers....
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