Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Host genetic determinants of T cell responses to the MRKAd5 HIV-1 gag/pol/nef vaccine in the step trial.

The Journal of infectious diseases - 15 Mar 2011

Fellay Jacques, Frahm Nicole, Shianna Kevin V, Cirulli Elizabeth T, Casimiro Danilo R, Robertson Michael N, Haynes Barton F, Geraghty Daniel E, McElrath M Juliana, Goldstein David B

Abstract excerpt

Understanding how human genetic variation impacts individual response to immunogens is fundamental for rational vaccine development. To explore host mechanisms involved in cellular immune responses to the MRKAd5 human immunodeficiency virus type 1 (HIV-1) gag/pol/nef vaccine tested in the Step trial, we performed a genome-wide association study of determinants of HIV-specific T cell responses, measured by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS Vaccines
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

Share to Gene Products, gag

Share to Genes, gag

Share to Genes, nef

Share to Genes, pol

Share to Regression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 21278214
DOI: 10.1093/infdis/jiq125
PMCID: PMC3071133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Host genetic determinants of T cell responses to the MRKAd5 HIV-1 gag/pol/nef vaccine in the step trial.PMID 21278214Read ↗

Vaccine-induced gag-specific T cells are associated with reduced viremia after HIV-1 infection.Semantic proximity Read ↗

Vaccinomics: current findings, challenges and novel approaches for vaccine development.Semantic proximity Read ↗

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques.Semantic proximity Read ↗

Host genetic variation and HIV disease: from mapping to mechanism.Semantic proximity Read ↗

Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles.Semantic proximity Read ↗

The challenges of host and viral diversity in HIV vaccine design.Semantic proximity Read ↗

Immunogenetics of HIV disease.Semantic proximity Read ↗

MRKAd5 HIV-1 Gag/Pol/Nef vaccine-induced T-cell responses inadequately predict distance of breakthrough HIV-1 sequences to the vaccine or viral load.Semantic proximity Read ↗

Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02.Semantic proximity Read ↗

Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics.Semantic proximity Read ↗

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.Semantic proximity Read ↗

Elevated HIV Infection of CD4 T Cells in MRKAd5 Vaccine Recipients Due to CD8 T Cells Targeting Adapted Epitopes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.