Article
Long-term mucosal T cell activation and homing phenotypes in recipients of an Ad5-vectored HIV vaccine.
Vaccine - 10 Aug 2020
Curlin Marcel E, Shao Jason, Diaz Gabriela, Edlefsen Paul T, Novak Richard M, Mayer Kenneth H, Allen Mary, Morgan Cecilia, Maenza Janine, Buchbinder Susan, Keefer Michael C, Rosa Stephen C De, Corey Lawrence, Duerr Ann
Abstract excerpt
BACKGROUND: Vaccine-induced mucosal immune responses may be critical for protection against HIV infection, but may also result in short or long-term changes that enhance susceptibility to infection in some individuals, such as those with baseline seroreactivity to vaccine vector antigens. We examined cellular immune responses in blood and gut mucosal tissue roughly two years following vaccination with placebo or...
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